NCT00710957

Vitamin D and Physical Function in Older Adults

Role of Vitamin D Status on Physical Function and Falls in Adults of Advanced Age

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 1,100 (actual)
• Sponsor: Wake Forest University Health Sciences · Academic / Other
• Sex: All
• Age: 79 Years
• Healthy volunteers: Accepted

Summary

Projections from NHANES III indicate that approximately 12,000,000 U.S. adults ≥ 60 years of age have vitamin D insufficiency (serum 25(OH)D \< 50 nmol/L). A growing body of evidence suggests that vitamin D status may be important in biologic processes involved in the maintenance of physical function. To test the hypothesis that vitamin D insufficiency is associated with poorer muscle strength and physical performance, we propose to evaluate the role of vitamin D status (serum 25(OH)D) on physical function and falls in the CHS All Stars cohort, a population of advanced age. The specific aims are as follows: Specific Aim 1. To describe the prevalence and correlates of vitamin D insufficiency in adults of advanced age. Specific Aim 2. To examine the cross-sectional association between vitamin D status and muscle strength (leg and grip strength), physical performance (3 m/15 ft walk time, repeated chair stands, and standing balance), self-reported physical function (mobility, ADL and IADL disability), and falls. Specific Aim 3. To examine the longitudinal association between vitamin D status at baseline and incident disability (mobility, ADL and IADL disability) over 3 years of follow-up. Research Hypotheses: Low vitamin D status (25(OH)D \< 50 nmol/L) will be associated with (a) lower levels of muscle strength and physical performance; (b) higher levels of self-reported limitations in physical function and falls; and (c) greater odds of incident disability.

Conditions

• Vitamin D
• Physical Function

Timeline

• Start date: 2008-04-01
• Primary completion: 2011-02-01
• Completion: 2011-02-01
• First posted: 2008-07-08
• Last updated: 2018-07-06