NCT00708851

NB-UVB Phototherapy With and Without Topical LCD Treatment: a Bilateral Pilot Study

A Clinical Evaluation of Safety & Efficacy of Adding an At-home Topical LCD Solution Regimen to Standard Narrowband UVB Phototherapy Administered 3 Times Weekly to Adults With Generalized Plaque Psoriasis.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: NeoStrata Company, Inc. · Industry
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine if combining a daily at-home regimen using an LCD Solution with a 3 times weekly outpatient narrowband UVB phototherapy regimen could be a safe, effective, rapid, and, convenient treatment for plaque psoriasis.

Detailed description

Use of coal tar with narrowband (NB) ultraviolet B (UVB) light (the Goeckermen regimen) is an effective treatment for plaque psoriasis that has become impractical in outpatient care mainly due to the inconvenience and aesthetic concerns of coal tar. This study aims to evaluate the safety, efficacy, and convenience of adding a novel liquor carbonis distillate (LCD) (coal tar) solution to standard NB\_UVB phototherapy in adults with chronic plaque psoriasis. Patients will apply LCD solution to half the body, twice daily at home and receive outpatient full-body NB-UVB light therapy 3 times a week for up to 12 weeks. A blinded investigator will grade psoriasis severity of body halves and bilateral target lesions and monitor adverse reactions. Patients will rate their psoriasis symptoms and LCD solution aesthetics. Incorporating an at-home regimen with a novel LCD solution into outpatient NB-UVB light therapy is safe, convenient, and effective and can improve psoriasis more quickly than NB-UVB light therapy alone.

Conditions

• Plaque Psoriasis

Interventions

Type	Name	Description
OTHER	LCD Solution with NB-UVB Phototherapy	LCD Solution: 2 applications / day NB-UVB Phototherapy: 3 light sessions / week
DEVICE	NB-UVB Light Device (311-315 nm)	NB-UVB Phototherapy: 3 light exposures / week

Timeline

• Start date: 2007-04-01
• Primary completion: 2008-01-01
• Completion: 2008-03-01
• First posted: 2008-07-02
• Last updated: 2015-04-20
• Results posted: 2015-04-20

Locations

1 site across 1 country: United States