NCT00708357

Does eNOS Gene Polymorphism Play a Role in the Maintenance of Basal Vascular Tone in the Choroid or Optic Nerve Head?

• Status: Terminated
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: Medical University of Vienna · Academic / Other
• Sex: Male
• Age: 19 Years
• Healthy volunteers: Accepted

Summary

Nitric oxide (NO) is a potent endothelium-derived vasodilatator that plays a major role in the control of ocular blood flow. Endothelial NO synthase (eNOS) is one of three isoforms of NOS producing NO through hydroxylation of L-arginine. The eNOS gene is located on the long arm of chromosome 7, and different polymorphic variations have been identified. These single nucleotide polymorphisms (sNP´s) have the ability to change transcription activity and therefore enzyme levels. Recent data indicate that the T -786C polymorphism (especially the homozygous variant) is associated with reduced eNOS activity and consequently impaired NO production. In the present study the investigators want to investigate if the T -786C eNOS gene polymorphism determines choroidal and optic nerve head blood flow.

Conditions

• Ocular Physiology
• Regional Blood Flow

Interventions

Type	Name	Description
DRUG	NG-monomethyl-L-arginine	intravenous administration, bolus over 5 minutes, dosage 6mg/kg

Timeline

• Start date: 2005-05-01
• Primary completion: 2009-12-01
• Completion: 2013-01-01
• First posted: 2008-07-02
• Last updated: 2014-11-17

Locations

1 site across 1 country: Austria