NCT00704548

Antihypertensive Effect of Simvastatin in Hypertensive Patients

Antihypertensive Effect of Simvastatin in Hypertensive Patients: a Randomized Clinical Trial With Ambulatory Blood Pressure Monitoring

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 92 (estimated)
• Sponsor: Hospital de Clinicas de Porto Alegre · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Few trials have investigated the hypotensive effect of the Statins. Most were not specifically aimed at this pleiotropic effect or had methodological problems. The possible hypotensive effect may explain part of the favorable results of the Statins use on cardiovascular prevention independently from its action on the cholesterol profile. The purpose of this study is to determine the effect of Simvastatin on the blood pressure

Detailed description

This is a randomized double blind parallel clinical trial where hypertensive patients with controlled or uncontrolled blood pressure and without evidence of target-organ damage will be selected. Subjects will receive Simvastatin 40 mg once daily or placebo and a baseline and eight weeks ABPM will performed. The main outcome will be the difference in systolic BP in the 24h-ABPM.

Conditions

• Hypertension

Interventions

Type	Name	Description
DRUG	Simvastatin 40mg	Simvastatin once daily, orally in the morning period, during eigth weeks
DRUG	Placebo	Placebo once daily, orally in the morning period, during eigth weeks

Timeline

• Start date: 2008-06-01
• Primary completion: 2009-09-01
• Completion: 2009-09-01
• First posted: 2008-06-25
• Last updated: 2009-06-26

Locations

1 site across 1 country: Brazil