NCT00700700

Cardiac Resynchronization Therapy, Dyspnea and Exercise Tolerance in Patients With Congestive Heart Failure (CHF)

Effects of Cardiac Resynchronization Therapy on Dyspnea and Exercise Tolerance in Patients With Congestive Heart Failure

• Status: Terminated
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 2 (actual)
• Sponsor: Queen's University · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

A new therapy for patients with advanced heart failure (HF) involves the implantation of a specialized pacemaker device (Cardiac Resynchronization Therapy, CRT) that attempts to restore the synchronized contraction of the ventricular chambers of the heart. In some people, CRT improves exertional breathlessness and allows them to exercise for longer periods. However, to date, the mechanisms by which CRT improves symptoms and exercise tolerance is unknown. This study will use in-depth cardiopulmonary exercise testing and pulmonary function testing to explore these mechanisms in greater detail.

Conditions

• Congestive Heart Failure

Interventions

Type	Name	Description
DEVICE	Active Cardiac Resynchronization Therapy (CRT)	Initiation of active biventricular pacing/cardiac resynchronization therapy Devices by Medtronic: 1. Insync Sentry 7298 \& 7299 2. Concerto C174 ASK (Most frequently implanted) 3. Insync III 8042 (PM) Devices by Guidant/Boston Scientific: 1. Contak Renewal 4 H190 \& H199 2. Contak Renewal 3 H127 Devices by ELA/Sorin: 1\. Ovatio CRT 6750

Timeline

• Start date: 2008-10-01
• Primary completion: 2011-06-01
• Completion: 2011-06-01
• First posted: 2008-06-19
• Last updated: 2011-07-06

Locations

1 site across 1 country: Canada