NCT00700518

Dose Response to Topical Glyceryl Trinitrate in Patients With Raynaud's Phenomenon

A Phase I Trial of the Pharmacodynamic Dose Response to Topical Trinitrate in Patients With Raynaud's Phenomenon

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 10 (estimated)
• Sponsor: Procris Pharmaceuticals · Industry
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to evaluate the blood flow response to topical Glyceryl Trinitrate when applied to the skin of patient's fingers with Raynaud's Phenomenon.

Conditions

• Raynaud's Phenomenon

Interventions

Type	Name	Description
DRUG	placebo cream	placebo cream applied to 2 adjacent fingers of non-dominant hand one time
DRUG	Glyceryl Trinitrate	0.6mg of Glyceryl Trinitrate applied to 2 adjacent fingers on non-dominant hand one time
DRUG	Glyceryl Trinitrate	1.2mg Glyceryl Trinitrate topically to 2 adjacent fingers of non-dominant hand one time
DRUG	Glyceryl Trinitrate	1.8mg Glyceryl Trinitrate topically to 2 adjacent fingers of non-dominant hand one time
DRUG	Glyceryl Trinitrate	2.4 mg Glyceryl Trinitrate topically to 2 adjacent fingers of non-dominant hand one time

Timeline

• Start date: 2008-06-01
• Primary completion: 2008-11-01
• Completion: 2008-11-01
• First posted: 2008-06-18
• Last updated: 2008-12-30

Locations

1 site across 1 country: United States