NCT00700037

Change in Plaque Characteristics With Atorvastatin

Effect of Atorvastatin Therapy on Fibrous Cap Thickness in Coronary Atherosclerotic Plaque as Assessed by Optical Coherence Tomography

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 70 (actual)
• Sponsor: Wakayama Medical University · Academic / Other
• Sex: All
• Age: 20 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

To examine effects of intensive lipid lowering therapy with atorvastatin on stabilization of coronary plaque by using optical coherence tomography (OCT) in patients with acute coronary syndrome.

Detailed description

Patients with acute coronary syndrome (myocardial infarction or unstable angina) who will undergo PCI and have at least one atherosclerotic lesion of \>25% stenosis other than culprit lesions of current ACS are enrolled. Fibrous cap thickness of a target coronary plaque is evaluated by optical coherence tomography.

Conditions

• Acute Coronary Syndrome
• Atherosclerosis
• Dyslipidemia

Interventions

Type	Name	Description
DRUG	high-dose atorvastatin	20mg/day
DRUG	low-dose atorvastatin	5mg/day

Timeline

• Start date: 2009-08-01
• Primary completion: 2012-02-01
• Completion: 2012-02-01
• First posted: 2008-06-18
• Last updated: 2014-10-29

Locations

1 site across 1 country: Japan