NCT00698204

Cox-2 Inhibition in Radiation-induced Oral Mucositis

Cyclooxygenase-2 Inhibition in Radiation-Induced Oral Mucositis

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 43 (actual)
• Sponsor: UConn Health · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Oral mucositis refers to ulcerative lesions of the oral mucosa that occur due to radiation therapy given for treatment of head and neck cancer. These lesions are painful, compromise nutrition and quality of life and may necessitate interruptions in radiation therapy, thus adversely affecting cancer therapy outcomes. This study examined the use of an anti-inflammatory medicine to reduce pain and severity of oral mucositis.

Conditions

• Oral Mucositis

Interventions

Type	Name	Description
DRUG	celecoxib	Subject was asked to take celecoxib each day that radiation therapy was given.
DRUG	placebo	Subject was asked to take placebo each day that radiation therapy was given.

Timeline

• Start date: 2003-07-01
• Primary completion: 2012-09-01
• Completion: 2013-12-01
• First posted: 2008-06-17
• Last updated: 2014-06-05
• Results posted: 2014-06-05

Locations

2 sites across 1 country: United States