NCT00695331

Efficacy and Safety Study of Titrated Oral Misoprostol Solution for Labor Augmentation

A Comparison of Titrated Oral Misoprostol Solution to Intravenous Oxytocin for Labor Augmentation: A Randomized Controlled Trial

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 143 (estimated)
• Sponsor: China Medical University Hospital · Academic / Other
• Sex: Female
• Age: 18 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to compare the efficacy and safety of titrated oral misoprostol solution with intravenous oxytocin for labor augmentation in women without adequate uterine contractions.

Detailed description

Numerous labor course necessitate augmentation when uterine contractions are inadequate. When the cervix is favorable, labor augmentation attempts are more likely to be successful. Augmentation is these women is traditionally undertaken with intravenous oxytocin and amniotomy, either alone or in combination. In our previous trial, it has been proven that the method of titrated oral misoprostol is associated with a lower incidence of uterine hyperstimulation and a lower cesarean delivery rate than vaginal misoprostol for labor induction in patients with unfavorable cervix. Because administering Misoprostol solution is easy and cost saving, it is worth to develop this novel method in labor augmentation.

Conditions

• Labor

Interventions

Type	Name	Description
DRUG	Misoprostol	Titrated Misoprostol Solution
DRUG	Oxytocin	Titrated Intravenous Oxytocin

Timeline

• Start date: 2008-02-01
• Primary completion: 2008-12-01
• Completion: 2009-01-01
• First posted: 2008-06-11
• Last updated: 2008-07-10

Locations

1 site across 1 country: Taiwan