NCT00693069

Effect of Different Dosing Regimens of Clopidogrel Before Elective Percutaneous Coronary Intervention (PCI) on Platelet Function

Effect of Different Dosing Regimens of Clopidogrel Given Before Elective Percutaneous Coronary Intervention on Platelet Function

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 120 (actual)
• Sponsor: Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

Adequate platelet inhibition before percutaneous coronary intervention (PCI) reduces peri-procedural and long-term ischemic complications. Documented reduced response to clopidogrel has been associated with subsequent major adverse cardiovascular events. Strategies to optimize platelet inhibition pre-PCI are under investigation. This study sought to evaluate the effect on platelet aggregation of four different dosing regimens of clopidogrel given before elective PCI.

Conditions

• Coronary Artery Disease

Interventions

Type	Name	Description
DRUG	Clopidogrel	clopidogrel 300 mg on the day prior to angiography
DRUG	Clopidogrel	clopidogrel 600 mg on the day prior to angiography
DRUG	Clopidogrel	clopidogrel 300 mg followed by 75 mg daily started one week prior to angiography
DRUG	Clopidogrel	clopidogrel 300 mg followed by 150 mg daily started one week prior to angiography

Timeline

• Start date: 2004-09-01
• Completion: 2006-04-01
• First posted: 2008-06-06
• Last updated: 2012-08-21

Locations

1 site across 1 country: Canada