NCT00687700

A Study to Investigate the Pharmacology of a Dual Pharmacophore in Healthy Volunteers

A Study to Investigate the Relative Pharmacological Activity of Aninhaled B2-agonist/Anticholinergic Dual Pharmacophore Inhealthy Volunteers

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 23 (actual)
• Sponsor: Theravance Biopharma · Industry
• Sex: Male
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

Study will investigate the pharmacodynamics of a dual pharmacophore in which a combination of GSK961081 and Propanolol is used to give a total effect of bronchodilation.

Conditions

• Pulmonary Disease, Chronic Obstructive

Interventions

Type	Name	Description
DRUG	GSK961081	GSK961081 multidose dry powder inhaler (Diskus inhaler) will be available with dosing strengths of 400 micrograms and 1200 micrograms administered once daily in the morning.
DRUG	GSK961081 matching placebo	GSK961081 matching placebo multidose dry powder inhaler (Diskus inhaler) will be available to be administered once daily in the morning.
DRUG	Propranolol	Propranolol over encapsulated tablet will be available with dosing strengths of 40 milligrams administered orally with 240 milliliters of water.
DRUG	Propranolol matching placebo	Propranolol matching placebo over encapsulated tablet will be available to be administered orally with 240 milliliters of water.

Timeline

• Start date: 2008-03-10
• Primary completion: 2008-05-27
• Completion: 2008-05-27
• First posted: 2008-06-02
• Last updated: 2021-10-06

Locations

1 site across 1 country: United Kingdom