NCT00687518

Effects of Intravenous Injection of Erythropoietin on Hepcidin Pharmacokinetics in Healthy Volunteers

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 14 (estimated)
• Sponsor: Rennes University Hospital · Academic / Other
• Sex: Male
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to measure the variations of serum and urinary hepcidin levels following a single intravenous injection of erythropoietin in healthy volunteers. Hepcidin is a major regulator of iron homeostasis. It acts by binding on ferroportin, and limits cellular efflux of iron through enterocytes and macrophages. Anemia and hypoxia are known to modulate hepcidin synthesis. In these situations, erythropoietin synthesis is increased, so it can be postulated that erythropoietin could modulate hepcidin synthesis.

Conditions

• Iron Metabolism Disorders

Interventions

Type	Name	Description
DRUG	Erythropoietin	Intravenous injection of 50 U/kg of erythropoietin
DRUG	Placebo	Intravenous injection of equivalent volume of saline serum

Timeline

• Start date: 2008-03-01
• Primary completion: 2008-11-01
• Completion: 2009-02-01
• First posted: 2008-05-30
• Last updated: 2008-05-30

Locations

1 site across 1 country: France