NCT00686972

The Effect of Surgically Induced Weight Loss on Endocrine Function, Cardiovascular Function and Body Composition

• Status: Terminated
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 51 (actual)
• Sponsor: Johns Hopkins University · Academic / Other
• Sex: All
• Age: 21 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This study is being conducted to evaluate changes in sugar, metabolism, heart function and changes in body composition as patients lose weight following bariatric surgery. The investigators will compare improvements of the above changes as a function of the four different types of bariatric surgery. The investigators believe the most beneficial and safest procedure will be the Roux-en-Y.

Detailed description

The study will also examine the response of the pancreas (the insulin-producing organ) to a sugar load, as well as to a hormone called Glucagon Like Peptide 1 (GLP-1), which is released from your gut to maximally stimulate your pancreas. The release of this hormone increases when you eat food and it causes the pancreas to release more insulin than does sugar alone. Volunteers will have 22 visits over a two year period. Only people having Roux-en-Y gastric bypass surgery, gastric sleeve surgery, duodenal switch gastric surgery or lap-band/gastric banding surgery may join. Seventy volunteers will be recruited to take part in this study.

Conditions

• Bariatric Surgery

Interventions

Type	Name	Description
DRUG	GLP-1	5 ng/kg/min, IV for 1 hour during each clamp study (7) over 2 year period.

Timeline

• Start date: 2007-05-01
• Primary completion: 2010-10-01
• Completion: 2010-10-01
• First posted: 2008-05-30
• Last updated: 2017-07-02
• Results posted: 2017-07-02

Locations

1 site across 1 country: United States