NCT00685867

Two Strategies for Methicillin-resistant Staphylococcus Aureus (MRSA) Infection Prevention in Surgical Patients

An Interventional Study to Evaluate the Impact of Two Innovative Strategies in Preventing Nosocomial MRSA Infection in Surgical Patients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 126,750 (actual)
• Sponsor: University Hospital, Geneva · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

The study is a two-arm controlled multi-centre trial of two strategies to reduce nosocomial MRSA transmission and infection among surgical patients. Enrolment and primary analyses will be performed at the hospital level. A total of ten adult surgical departments with at least 3 surgical subspecialties each will participate in the study. Sites of the study are located in 9 countries (UK, France, Spain, Germany, Switzerland, Italy, Serbia, Greece and Israel). The primary objective is to determine the effect of an early MRSA detection \& decolonization \& isolation strategy compared to an enhanced standard control strategy on healthcare-associated MRSA isolation rates among surgical patients at risk of MRSA carriage, who are hospitalized for at least 24 hours.

Conditions

• MRSA Infection

Interventions

Type	Name	Description
OTHER	Rapid molecular MRSA test	PCR-based rapid screening for MRSA carriage
BEHAVIORAL	Hand hygiene promotion	* Promotion and monitoring of hand hygiene, with special emphasis on alcohol-based hand rubs and feedback of hand hygiene compliance * Standard precautions (e.g. use of gloves for contacts with wounds and body fluids) * Isolation precautions according to the hospitals' capacity and strategy * Additional basic infection control interventions (if necessary)

Timeline

• Start date: 2008-05-01
• Primary completion: 2010-12-01
• Completion: 2010-12-01
• First posted: 2008-05-29
• Last updated: 2012-08-21

Locations

1 site across 1 country: Switzerland