NCT00682812

Significance of the High-risk Hpv Viral Load

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 149 (actual)
• Sponsor: Assistance Publique Hopitaux De Marseille · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to evaluate the significance of an elevated high-risk HPV (HR-HPV) viral load.

Detailed description

We will particularly evaluate if the HR-HPV viral load: * Is correlated to the transcription of the genes of the oncoproteins E6 and E7 * Is predictive of the integration of the virus in infected cells * Is predictive of the presence of HPV in patients' blood * Influences the local and systemic immunologic response

Conditions

• HPV Infections

Interventions

Type	Name	Description
OTHER	2 cervical takings and 2 sampling of blood	* 2 cervical takings * 2 sampling of blood before and after the total hysterectomy
OTHER	2 cervical takings and 2 sampling of blood	* cervical taking during the cervical conization * 2 sampling of blood before and after the intervention
OTHER	2 cervical takings and 2 sampling of blood	* cervical taking during the pelvien examination under general anesthetic realized systematically during the balance sheet of pre-therapeutic evaluation * 2 sampling of blood before and after the intervention

Timeline

• Start date: 2008-06-16
• Primary completion: 2014-04-24
• Completion: 2023-05-23
• First posted: 2008-05-22
• Last updated: 2023-05-24

Locations

1 site across 1 country: France