NCT00679653

Blood Pressure and Weight Trajectory on a Dual Antihypertensive Combination Plus Sibutramine Versus Placebo in Obese Hypertensives

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 171 (actual)
• Sponsor: Abbott · Industry
• Sex: All
• Age: 20 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

To study the effect of sibutramine treatment on weight reduction and blood pressure improvement in three groups with antihypertensive therapy whose blood pressure was not adequately controlled with antihypertensive combination treatment.

Conditions

• Obesity
• Hypertension

Interventions

Type	Name	Description
DRUG	sibutramine	8-wks, sibutramine, 10 mg, capsules, once daily
DRUG	sibutramine	8-wks, sibutramine, 15 mg, capsules, once daily
DRUG	verapamil/trandolapril	2 wk Run-in phase, antihypertensive therapy only
DRUG	metoprolol/HCT	2 wk Run-in phase, antihypertensive therapy only
DRUG	felodipine/ramipril	2 wk Run-in phase, antihypertensive therapy only

Timeline

• Start date: 2002-02-01
• Primary completion: 2003-12-01
• First posted: 2008-05-19
• Last updated: 2008-05-19