NCT00678184

The Effect of Atorvastatin on Renal Function in Healthy Subjects During Normal and High Sodium Intake

The Effect of Acute HMG-CoA-Reductase Inhibition (Atorvastatin) on Renal Sodium Excretion, Renal Hemodynamics, Tubular Function and Vasoactive Hormones in Healthy Subjects During Normal and High Sodium Intake

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 23 (actual)
• Sponsor: Regional Hospital Holstebro · Academic / Other
• Sex: All
• Age: 20 Years – 50 Years
• Healthy volunteers: Accepted

Summary

We wanted to test the hypothesis that acute treatment with atorvastatin changes renal sodium handling, renal hemodynamics, tubular function and vasoactive hormones in healthy humans during normal and high sodium intake.

Detailed description

We wanted to test the hypothesis that acute treatment with atorvastatin changes renal sodium handling, renal hemodynamics, tubular function and vasoactive hormones in healthy humans during normal and high sodium intake. We wanted to analyze if changes in renal hemodynamics, tubular function, hormones, blood pressure and HR under acute treatment with atorvastatin depends on sodium intake.

Conditions

• Healthy Subjects

Interventions

Type	Name	Description
DRUG	Atorvastatin	80 mg atorvastatin on two following days each

Timeline

• Start date: 2007-01-01
• Primary completion: 2007-10-01
• Completion: 2007-10-01
• First posted: 2008-05-15
• Last updated: 2008-05-15

Locations

2 sites across 1 country: Denmark