NCT00674570

Veteran Stress and Learning Study

Effects of Hydrocortisone and D-Cycloserine on Fear Extinction in Veterans With Posttraumatic Stress Disorder

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 111 (actual)
• Sponsor: VA Office of Research and Development · Federal
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

This is a research study examining the use of two medications, Hydrocortisone and D-Cycloserine, compared to an inactive substance (placebo), on their ability to reduce fear responses and memory of fear in Veterans with symptoms of Posttraumatic Stress Disorder (PTSD). These responses will be tested using a fear learning and memory task administered by computer.

Conditions

• Stress Disorders, Posttraumatic

Interventions

Type	Name	Description
DRUG	Hydrocortisone	25 mg/oral one hour prior to extinction task
DRUG	D-Cycloserine	50 mg/oral one hour prior to extinction task
DRUG	Placebo	One hour prior to extinction task

Timeline

• Start date: 2009-01-13
• Primary completion: 2015-06-22
• Completion: 2015-06-22
• First posted: 2008-05-08
• Last updated: 2019-05-30
• Results posted: 2019-05-30

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study