NCT00673894

Effects of Glutamine on GLP-1 and Insulin Secretion in Man

Study of the Effects of Glutamine on Glycemia, Glucagon-like Peptide-1 (GLP-1) and Insulin Secretion in Man

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 22 (actual)
• Sponsor: Garvan Institute of Medical Research · Academic / Other
• Sex: All
• Age: 40 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

This study investigated the effect of glutamine, an amino acid, glycemia, glucagon-like peptide-1 (GLP-1) and insulin in participants with type 2 diabetes.

Detailed description

In this study, we investigated the effect of glutamine, an amino acid, on glycemia and on GLP-1 and insulin in participants with type 2 diabetes. Preliminary data published by our group suggests that glutamine is a strong determinant of GLP-1 secretion in vitro. We tested the hypothesis that glutamine lowers postprandial blood glucose and investigated whether the dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin modifies this effect.

Conditions

• Type 2 Diabetes

Interventions

Type	Name	Description
DRUG	Sitagliptin	Glutamine 30g +sitagliptin 100mg
DRUG	Placebo	Glutamine 30g +placebo (matching sitagliptin 100 mg)

Timeline

• Start date: 2008-04-01
• Primary completion: 2011-12-01
• Completion: 2014-11-01
• First posted: 2008-05-07
• Last updated: 2019-05-13
• Results posted: 2019-05-13

Locations

1 site across 1 country: Australia