NCT00672347

Clonidine and Morphine in Caudal Anesthesia

Comparison of Clonidine and Morphine Plus Bupivacaine in Caudal Peridural Anesthesia for Postoperative Analgesia After Pediatric Urogenital Surgery

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: Federal University of Minas Gerais · Academic / Other
• Sex: All
• Age: 1 Year – 10 Years
• Healthy volunteers: Not accepted

Summary

Hypothesis: The combined use of Clonidine and Morphine in caudal anesthesia provides better postoperative analgesia than either drug alone after urogenital pediatric surgery.

Detailed description

It is a randomized, double blind study, involving 80 children with ages from 1 to 10 years old, submitted to urogenital surgery, under general anesthesia and caudal block. The patients will be divided into 4 groups: bupivacaine alone, bupivacaine plus clonidine, bupivacaine plus morphine, bupivacaine plus clonidine and morphine. The peroperative consumption of analgesics and inhaled gases, BIS, heart rate and arterial blood pressure will be recorded. Postoperative pain will be evaluated by using Wong-Baker faces scale and pain and discomfort score scale, as well as the consumption of analgesics.

Conditions

• Postoperative Pain

Interventions

Type	Name	Description
DRUG	Clonidine	1 mcg/kg
DRUG	Morphine	20 mcg/kg
DRUG	Bupivacaine plus clonidine and morphine	bupivacaine 0,166% 1 ml/kg clonidine 1 mcg/kg morphine 20 mcg/kg
DRUG	Bupivacaine	Caudal anesthesia with bupivacaine 0,166% 1 ml/kg

Timeline

• Start date: 2008-07-01
• Primary completion: 2008-09-01
• Completion: 2009-09-01
• First posted: 2008-05-06
• Last updated: 2010-03-19

Locations

1 site across 1 country: Brazil