NCT00668876

Effects of Immunonutrition in Patients Undergoing Pancreaticoduodenectomy

Effects of Immunonutrition on Surgical Site Infection and Th1/Th2/Th17 Differentiation in Patients Undergoing Pancreaticoduodenectomy

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Chiba University · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine whether immunonutrition is effective on surgical site infection and Th1/Th2/Th17 differentiation in patients undergoing pancreaticoduodenectomy

Detailed description

Perioperative immunonutrition is reported to improve the incidence of postoperative infectious complication in patients with gastrointestinal surgery. It has also been recognized that Th1/Th2 balance shifts toward Th2 by surgical stress. On the other hand, the change of Th17 status after surgery has not been established. Furthermore, The change of Th1/Th2 balance and Th17 status with immunonutrition on pancreaticoduodenectomy have not been reported yet. Objective of this study is to investigate the effects of perioperative immunonutrition on incidence of postoperative infectious complication, Th1/Th2 balance and Th17 status after pancreaticoduodenectomy.

Conditions

• Pancreaticoduodenectomy

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Oral IMPACT	oral supplementation for 5 days(1 L/d )before surgery of a formula enriched with arginine, omega-3 fatty acids, and RNA
DIETARY_SUPPLEMENT	Oral IMPACT	postoperative enteral infusion of the formula with arginine, omega-3 fatty acids, and RNA
DIETARY_SUPPLEMENT	Parenteral nutrition	Parenteral nutrition

Timeline

• Start date: 2006-05-01
• Primary completion: 2008-01-01
• Completion: 2008-09-01
• First posted: 2008-04-29
• Last updated: 2008-12-03

Locations

1 site across 1 country: Japan