NCT00667589

Sorafenib-induced Hand- Foot Skin Reaction Treatment

Four-arm Study to Evaluate Urea 40% Cream, Fluocinonide 0.05% Cream, Tazarotene 0.1% Cream, and an Emollient Cream for the Treatment of Hand-foot Skin Reaction Related to the Use of Multi-targeted Tyrosine Kinase Inhibitor Sorafenib.

• Status: Terminated
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 6 (actual)
• Sponsor: Northwestern University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to evaluate treatments for a rash caused by sorafenib.

Detailed description

This study will compare compare the effectiveness of four creams (urea 40% cream, fluocinonide 0.05% cream, tazarotene 0.1% cream, and Udderly smooth® Udder Cream) in treating hand-foot skin reaction (HFSR), a rash caused by sorafenib.

Conditions

• Hand-foot Skin Reaction
• Rash

Interventions

Type	Name	Description
DRUG	urea 40% cream	urea 40% cream applied twice per day to affected areas
DRUG	fluocinonide 0.05% cream	fluocinonide 0.05% cream applied twice per day to affected areas
DRUG	tazarotene 0.1% cream	tazarotene 0.1% cream applied twice per day to affected areas
DRUG	bland emollient cream (Udderly smooth® Udder Cream)	bland emollient cream applied twice per day to affected areas

Timeline

• Start date: 2008-06-01
• Primary completion: 2010-12-01
• Completion: 2010-12-01
• First posted: 2008-04-28
• Last updated: 2013-06-05
• Results posted: 2013-05-27

Locations

1 site across 1 country: United States