NCT00666510

Bronchospasm Associated With High Nitric Oxide

Higher Exhaled Nitric Oxide (NO) is Associated With Intraoperative Bronchospasm

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 31 (actual)
• Sponsor: University of Sao Paulo · Academic / Other
• Sex: All
• Age: 16 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Intraoperative bronchospasm challenges anesthesia's safety. This study aims to investigate high concentration of exhaled nitric oxide as a marker of intraoperative bronchospasm.

Detailed description

Previous studies in asthmatic patients suggested that exhaled nitric oxide may represent a noninvasive measure for airway inflammation. Anesthesia information forms from 1999 throughout 2004 were revised (n=146.358). Bronchospasm occurrence appeared registered on 863 forms. From those, nine were identified as non-asthmatics patients (Bronchospasm group). Also, 12 asthmatics constituted one additional group (Asthma group) and 10 subjects with no previous airway disease or symptoms (Control group). All subjects were submitted to Exhaled nitric oxide measurements (parts/billion), spirometry and induced sputum.

Conditions

• Asthma
• Airway Hyperresponsiveness

Timeline

• Start date: 1999-01-01
• Completion: 2004-12-01
• First posted: 2008-04-25
• Last updated: 2008-04-25

Locations

1 site across 1 country: Brazil