NCT00664209

Treating H. Pylori in Parkinson's Patients With Motor Fluctuations

Helicobacter Pylori Eradication and Motor Fluctuations in Parkinson's Disease

• Status: Terminated
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 64 (actual)
• Sponsor: University of California, Los Angeles · Academic / Other
• Sex: Male
• Age: —
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine whether treatment of H. pylori (an infection of the stomach) improves treatment effectiveness in patients with Parkinson's disease and motor fluctuations.

Detailed description

Previous investigations have demonstrated that treatment of Helicobacter pylori with antibiotics leads to improved absorption and pharmacokinetics of levodopa. This may potentially benefit patients with Parkinson's disease who have motor fluctuations, specifically excessive "off" time, when their levodopa is not working to control symptoms. We seek to identify the frequency of H. pylori infection in this population using standard lab assays and determine whether eradication with standard triple therapy results in improved clinical response to medication.

Conditions

• Parkinson's Disease
• Helicobacter Infections
• Motor Fluctuations

Interventions

Type	Name	Description
DRUG	clartihromycin, amoxicillin, and omeprazole	clarithromycin 500mg - i PO BID x10 days; amoxicillin 1gm - i PO BID x10 days; omeprazole 10mg - i PO BID x10 days
DRUG	placebo	placebo therapy

Timeline

• Start date: 2008-01-01
• Primary completion: 2011-06-01
• Completion: 2012-06-01
• First posted: 2008-04-22
• Last updated: 2017-12-02
• Results posted: 2017-12-02

Locations

1 site across 1 country: United States