NCT00660075

Effects of Sitagliptin on Postprandial Lipemia in Men With Type 2 Diabetes

A Randomized, Double-Blind, Placebo-Controlled, Crossover Study To Evaluate The Effects of Sitagliptin on Postprandial Plasma Lipoprotein Concentrations in Men With Type 2 Diabetes

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 36 (actual)
• Sponsor: Laval University · Academic / Other
• Sex: Male
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Sitagliptin is a potent and selective inhibitor of dipeptidyl peptidase IV (DPP-4), and has been shown to reduce fasting and postprandial glucose levels in patients with type 2 diabetes mainly through incretin hormone-mediated improvements in islet function. Although clinical studies to date indicate that fasting lipid levels are minimally affected by DPP-4 inhibitor treatment, animal studies suggested that DPP-4 inhibition reduce intestinal triglyceride (TG) absorption and apolipoprotein production and increased chylomicron catabolism. Therefore, the present study was designed to examine the effects of sitagliptin on postprandial lipemia in patients with type 2 diabetes. A possible reduction in postprandial atherogenic triglyceride-rich lipoproteins (TRL) levels by sitagliptin would add to therapeutic utility of this DPP-4 inhibitor and suggest the potential to reduce cardiovascular risk in patients with type 2 diabetes.

Conditions

• Diabetes Mellitus
• Postprandial Lipemia

Interventions

Type	Name	Description
DRUG	Sitagliptin	Sitagliptin 100 mg/d for 6 weeks
DRUG	Placebo	Placebo for 6 weeks

Timeline

• Start date: 2008-02-01
• Primary completion: 2009-01-01
• Completion: 2009-04-01
• First posted: 2008-04-17
• Last updated: 2012-12-11
• Results posted: 2012-12-11

Locations

1 site across 1 country: Canada