NCT00657306

Adrenal Insufficiency in Cirrhotics With Ascites. Effects of Hydrocortisone on Renal and Haemodynamic Function

Adrenal Insufficiency in Cirrhotics With Ascites. Effects of Stress Doses of Hydrocortisone on Renal Function and on Liver and Systemic Haemodynamics

• Status: Unknown
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: University of Turin, Italy · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Relative adrenal insufficiency (RAI) is an well known condition in patients with septic shock. Liver failure (including chronic liver failure)and sepsis are both characterized by hyperdynamic circulatory failure (with low arterial pressure) and high levels of pro-inflammatory cytokines. Hydrocortisone has been shown to have a beneficial effect on clinical outcome. The aim of this study is to evaluate the incidence of RAI in the different settings of ascites in cirrhosis and the usefulness of hydrocortisone in this context.

Conditions

• Cirrhosis With Ascites

Interventions

Type	Name	Description
DRUG	hydrocortisone	50 mg/6 h per day
DRUG	dextrose solution 5%	dextrose solution 5% 100 ml/6 h per day

Timeline

• Start date: 2008-05-01
• Primary completion: 2008-12-01
• Completion: 2009-05-01
• First posted: 2008-04-14
• Last updated: 2008-04-14

Locations

1 site across 1 country: Italy