NCT00655928

Modulation of Lung Injury Complicating Lung Resection

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 52 (actual)
• Sponsor: Imperial College London · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine whether N-acetylcysteine given intravenously 1 day pre-operatively is effective in preventing inflammation in the lungs, as measured by tests on blood, breath and lung specimens, in patients undergoing surgery to remove a portion of lung.

Detailed description

Acute lung injury occurs following lung resection in about 5% cases, and has a high mortality of around 50%. Management of these patients is largely supportive. Even in patients who do not develop clinical evidence of acute lung injury, markers of inflammation and oxidative stress are present in blood and exhaled breath condensate after lung resection. The purpose of this randomised double-blind placebo-controlled study is to determine whether lung injury can be prevented by pre-administration of N-acetylcysteine.

Conditions

• Acute Lung Injury

Interventions

Type	Name	Description
DRUG	N-acetylcysteine	N-acetylcysteine 240mg/kg in 1 litre 0.9% saline intravenous over 12 hours pre-operatively
DRUG	0.9% saline	0.9% saline 1 litre intravenous over 12 hours pre-operatively

Timeline

• Start date: 2007-08-01
• Primary completion: 2009-07-01
• Completion: 2009-07-01
• First posted: 2008-04-10
• Last updated: 2020-02-05
• Results posted: 2019-09-23

Locations

1 site across 1 country: United Kingdom