NCT00655642

Comparison of Ondansetron, Metoclopramide and Promethazine for the Treatment of Nausea and Vomiting in the Adult ED

A Randomized, Double Blind, and Placebo-Controlled Trial Comparing Ondansetron, Metoclopramide and Promethazine for the Treatment of Nausea and Vomiting in the Adult Emergency Department.

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 171 (actual)
• Sponsor: Vanderbilt University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to compare the effectiveness of ondansetron, metoclopramide, and promethazine for the treatment of nausea in the adult emergency department population. We hypothesize that a single intravenous dose of ondansetron is more effective in reducing nausea than a single IV dose of metoclopramide, promethazine or normal saline placebo in undifferentiated adult emergency department patients.

Conditions

• Nausea

Interventions

Type	Name	Description
DRUG	Ondansetron	4 mg intravenous dose administered over 2 minutes through a peripheral intravenous catheter
DRUG	Metoclopramide	10 mg intravenous dose administered over 2 minutes through a peripheral intravenous catheter
DRUG	Promethazine	12.5 mg intravenous dose administered over 2 minutes through a peripheral intravenous catheter
DRUG	Normal Saline	Volume matched isotonic sodium chloride solution dose administered over 2 minutes through a peripheral intravenous catheter

Timeline

• Start date: 2007-03-01
• Primary completion: 2008-10-01
• Completion: 2008-10-01
• First posted: 2008-04-10
• Last updated: 2013-10-30
• Results posted: 2011-05-09

Locations

1 site across 1 country: United States