NCT00654290

Effect of Prophylaxy of Amiodarone and Propranolol and Amiodarone With Propranolol in Prevention of Atrial Fibrillation Post Coronary Artery Bypass Graft

Effect of Prophylaxy of Amiodarone and Propranolol and Amiodarone With Propranolol in Prevention of Atrial Fibrillation Post Coronary Artery Bypass Graft, A Prospective Double-Blind Randomized Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 240 (actual)
• Sponsor: Shiraz University of Medical Sciences · Academic / Other
• Sex: All
• Age: 45 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Atrial fibrillation is the most common arrhythmia post coronary bypass surgery, currently B-blockers are the class I indication to prevent AF post CABG. We decide to evaluate use of propranolol and amiodarone separately and together to find a better prophylaxis for AF peri-CABG

Detailed description

In this double blind randomized study 240 consecutive patients underwent elective coronary artery bypass grafting, being randomized prospectively into three groups, propranolol (p) (n=80), amiodarone (A) (n=80) and amiodarone with propranolol (AP) (n=80). All groups received their medications from 7 days preoperatively and continued their medications for 5 days post CABG.

Conditions

• Atrial Fibrillation

Interventions

Type	Name	Description
DRUG	Amiodarone + Propranolol	Amiodarone and Propranolol 7 days pre-operation to 5 days post CABG
DRUG	Amiodarone	Amiodarone treated 7 days pre-operation to 5 days post CABG
DRUG	Propranolol	Propranolol from 7 days pre-operation to 5 days post CABG

Timeline

• Start date: 2007-03-01
• Primary completion: 2008-01-01
• Completion: 2008-02-01
• First posted: 2008-04-07
• Last updated: 2008-04-07

Locations

1 site across 1 country: Iran