NCT00654134

Inhalation of 20,000 Endotoxin Units(EU) of Clinical Center Reference Endotoxin in Healthy Volunteers

Inhalation of 20,000 EU of Clinical Center Reference Endotoxin in Healthy Volunteers

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: University of North Carolina, Chapel Hill · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine the inflammatory response to 20,000 endotoxin units (EU) of CCRE (Clinical Center Reference Endotoxin) inhalation in a cohort of healthy volunteers. Preferably these subjects will have participated in ozone exposure studies, allowing a direct comparison of their responses to both endotoxin and ozone. Additionally, cardiovascular endpoints will be investigated with the CCRE exposure.

Conditions

• Healthy Adults

Interventions

Type	Name	Description
BIOLOGICAL	Clinical Center Reference Endotoxin	20,000 EU inhaled

Timeline

• Start date: 2005-10-01
• Primary completion: 2013-07-01
• Completion: 2013-07-01
• First posted: 2008-04-07
• Last updated: 2013-08-09

Locations

1 site across 1 country: United States