Trials / Completed
CompletedNCT00652301
A Research Study to Evaluate MK0653 (Ezetimibe) and Simvastatin, Given Together and Alone, on Intestinal Absorption of Cholesterol (0653-050)(COMPLETED)
A Randomized, Double-Blind, Placebo-Controlled,4-Period, Crossover Study to Evaluate the Effects of Ezetimibe and Simvastatin, Coadministered and Alone, on Intestinal Absorption of Cholesterol
- Status
- Completed
- Phase
- Phase 3
- Study type
- Interventional
- Enrollment
- 40 (actual)
- Sponsor
- Organon and Co · Industry
- Sex
- Male
- Age
- 18 Years – 55 Years
- Healthy volunteers
- Accepted
Summary
To determine the effect of ezetimibe and simvastatin given together, and ezetimibe and simvastatin given alone on intestinal cholesterol absorption.
Detailed description
Patients will be randomized into 1 of 4 treatment sequences involving 4 consecutive 7-week treatment periods.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | ezetimibe | ezetimibe 10 mg tablet. Duration of Treatment 31 Weeks. |
| DRUG | Comparator: Placebo (unspecified) | matching placebo tablet. Duration of Treatment 31 Weeks. |
| DRUG | simvastatin | simvastatin 20 mg tablet. Duration of Treatment 31 Weeks. |
Timeline
- Start date
- 2003-07-01
- Primary completion
- 2004-04-01
- Completion
- 2004-04-01
- First posted
- 2008-04-03
- Last updated
- 2024-08-15
Source: ClinicalTrials.gov record NCT00652301. Inclusion in this directory is not an endorsement.