NCT00642551

Beneficial Effects of Long Term Menaquinone-7

Clinical Trial on Beneficial Effects of Long Term Menaquinone-7 (Vitamin K2) Intake by Postmenopausal Women

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 240 (actual)
• Sponsor: Maastricht University Medical Center · Academic / Other
• Sex: Female
• Age: 55 Years – 65 Years
• Healthy volunteers: Accepted

Summary

From all K-vitamins, menaquinone-7 (MK-7) has been identified now as the most effective cofactor for the carboxylation reaction of Gla-proteins such as osteocalcin (in bone) and matrix-Gla protein (in the arterial vessel wall). The question remains whether supplementation with MK-7 also leads to measurable improvements of bone and vascular health. The purpose of the study is to demonstrate that MK-7 has a health benefit in apparently healthy postmenopausal women. In a placebo-controlled randomized clinical trial the effect of an MK-7- supplement will be monitored during three years on bone quantity and quality and on vascular characteristics and function.

Conditions

• Bone Loss
• Arteriosclerosis

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	menaquinone-7	180 µg menaquinone-7 daily for three years
DIETARY_SUPPLEMENT	placebo	1 placebo capsule daily for three years

Timeline

• Start date: 2008-03-01
• Primary completion: 2011-09-01
• Completion: 2011-09-01
• First posted: 2008-03-25
• Last updated: 2012-06-12

Locations

1 site across 1 country: Netherlands