NCT00639210

BREAST CANCER AND EXERCISE

BREAST CANCER AND EXERCISE BREX: A Multicenter Phase III Open Randomised Trial of the Efficacy of Exercise in the Prevention of Long-term Adverse Effects of Adjuvant Treatments and Breast Cancer Recurrences in Women With Primary Breast Cancer.

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 573 (actual)
• Sponsor: Finnish Breast Cancer Group · Academic / Other
• Sex: Female
• Age: 35 Years – 68 Years
• Healthy volunteers: Not accepted

Summary

A Finnish Breast Cancer Group Study (BREX 01-2004). A multicenter phase III open randomised trial of the efficacy of exercise in the prevention of long-term adverse effects of adjuvant treatments and breast cancer recurrences in women with primary breast cancer. The aim of the study is to investigate whether regular exercise training could reduce the long-term side effects of adjuvant treatments of primary breast cancer and improve quality of life and well being.

Detailed description

A multicenter phase III open randomised trial of the efficacy of exercise in the prevention of long-term adverse effects of adjuvant treatments and breast cancer recurrences in women with primary breast cancer. The aim of the study is to investigate whether regular exercise training could reduce the long-term side effects of adjuvant treatments of primary breast cancer and improve quality of life and well being. Large controlled prospective studies are needed to confirm the preliminary findings of exercises benefits in cancer patients, and to investigate the type, the frequency, intensity and tolerability of exercise training in cancer patients, before any clinical recommendations can be given. Prevention of osteoporosis, improvement of weight control, and muscular and cardiovascular fitness is been waited. The second aim of the study is to investigate, whether regular exercise training reduces the risk of breast cancer recurrence, prevents other diseases and reduce all-cause mortality and is cost effective in women with primary breast cancer.

Conditions

• Prevent Osteoporosis and Osteoporotic Fractures
• Improve Quality of Life
• Improve Weight Control, and Muscular and Cardiovascular Fitness
• Help the Patients to Return to Working Life
• Reduce the Risk of Breast Cancer Recurrence
• Reduce All-cause Mortality in Patients With Primary Breast Cancer

Interventions

Type	Name	Description
OTHER	supervised training	Design: supervised training is organised for the exercise group once a week in groups of 10 to 15 subjects. The training is guided by an experienced physical therapist.Content: The supervised training of the exercise group consists of two different classes alternating at four week periods; step aerobics class and circuit training class. The 60-minute aerobics and circuit training classes also include warming-up and cooling-down periods both lasting 10-15 minutes.

Timeline

• Start date: 2005-09-01
• Primary completion: 2007-09-01
• Completion: 2007-09-01
• First posted: 2008-03-20
• Last updated: 2019-02-26

Locations

1 site across 1 country: Finland