NCT00638729

Clonidine Versus Midazolam for Premedication

Effects of Clonidine and Midazolam Premedication on Bispectral Index and Recovery After Elective Surgery

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: University Hospital Schleswig-Holstein · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

alpha2-agonists like clonidine offer several useful effects that make these drugs an interesting alternative to benzodiazepines for pharmacological premedication. We therefore sought to determine the effect of pre-anesthetic medication with clonidine vs. midazolam in a randomized, double-blind, placebo controlled study. Effects of pre-anesthetic medication were assessed on (1) bispectral index (BIS),(2) sedation score and visual analog scales for anxiety and pain, (3) neuropsychologic tests to assess cognitive function and (4) circulating stress hormones.

Conditions

• Anxiety
• Pain

Interventions

Type	Name	Description
DRUG	midazolam	midazolam, 7.5 mg p.o., 60-90 min prior to estimated induction time
DRUG	clonidine	pre-anesthetic medication with clonidine, 150 µg p.o., 60-90 min prior to estimated induction time
DRUG	placebo	inert tablet p.o., 60-90 min prior to estimated induction time

Timeline

• Start date: 2005-08-01
• Primary completion: 2007-03-01
• Completion: 2007-03-01
• First posted: 2008-03-19
• Last updated: 2008-03-19

Locations

1 site across 1 country: Germany