Trials / Completed
CompletedNCT00637936
Respiratory Effects of Perioperative Oxygen During General Anaesthesia
Perioperative Oxygen Fraction - Effects on the PaO2/FiO2-Index During Laparotomy
- Status
- Completed
- Phase
- Phase 4
- Study type
- Interventional
- Enrollment
- 35 (actual)
- Sponsor
- University of Copenhagen · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
Aim: To investigate the effect of high intra- and postoperative oxygen concentration (80%, as opposed to normally 30%) on pulmonary gas exchange and other pulmonary complications after abdominal surgery. Background: Previous studies have shown possible beneficial effects of high perioperative oxygen concentration on surgical wound infection and healing, but all pulmonary effects are not clarified. Change in perioperative PaO2/FiO2 and shunt-fraction, measured by a gas rebreathing technique, can describe pulmonary oxygenation. This could add knowledge to the pulmonary effects of high vs. normal oxygen concentration. Primary hypothesis of study: Perioperative use of a 80% oxygen concentration reduces the PaO2/FiO2-index compared to 30% oxygen.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Oxygen | Inspiratory fraction during anaesthesia |
Timeline
- Start date
- 2008-03-01
- Primary completion
- 2008-08-01
- Completion
- 2008-08-01
- First posted
- 2008-03-18
- Last updated
- 2009-01-12
Source: ClinicalTrials.gov record NCT00637936. Inclusion in this directory is not an endorsement.