NCT00634491

Comparison Between Effect of Acetazolamide and NaHco3 in Prevention of Contrast Nephropathy

Effect of Acetazolamide in Prevention of Contrast Nephropathy

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 240 (actual)
• Sponsor: Shiraz University of Medical Sciences · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is whether Acetazolamide is effective in prevention of contrast nephropathy

Detailed description

Contrast induced nephropathy is one of common causes of acute renal failure many preventive protocol existed . 240 patient that underwent coronary angiography randomly divided in three groups.Group 1,2,3 will receive Bicarbonate ,Acetazolamide+Normal salin and Normal salin respectively.We compare prevalence of contrast nephropathy in each group.

Conditions

• Contrast Induced Nephropathy

Interventions

Type	Name	Description
DRUG	sodium bicarbonate	150 meq/l Sodium bicarbonate 3cc/kg/hr before and 1cc/kg/hr after angiography
DRUG	Acetazolamide	Acetazolamide 250 mg+ 1 cc/kg/hr normal salin before and after angiography
DRUG	normal salin	1 cc/kg/hr 6 hour before and after angiography

Timeline

• Start date: 2007-09-01
• Primary completion: 2008-02-01
• Completion: 2008-02-01
• First posted: 2008-03-13
• Last updated: 2008-03-13

Locations

1 site across 1 country: Iran