NCT00631514

Interaction Between Antihypertensives and Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

Relevance of the Interaction Between Antihypertensive and Antirheumatic Drugs in a Family Practice

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 88 (actual)
• Sponsor: University of Split · Academic / Other
• Sex: All
• Age: 55 Years – 78 Years
• Healthy volunteers: Not accepted

Summary

NSAIDs may increase blood pressure and blunt the effects of many antihypertensives. Members of these drug classes differ in their propensity to such an interaction.

Detailed description

To compare prospectively the effects of piroxicam, ibuprofen and acetaminophen on blood pressure control in hypertensive patients with osteoarthritis.

Conditions

• Hypertension

Interventions

Type	Name	Description
DRUG	acetaminophen	acetaminophen 1000 mg t.i.d. per os ibuprofen 400-600 mg t.i.d. per os piroxicam 10-20 mg o.d. per os
DRUG	ibuprofen	acetaminophen 1000 mg t.i.d. per os ibuprofen 400-600 mg t.i.d. per os piroxicam 10-20 mg o.d. per os
DRUG	piroxicam	acetaminophen 1000 mg t.i.d. per os ibuprofen 400-600 mg t.i.d. per os piroxicam 10-20 mg o.d. per os

Timeline

• Start date: 2005-01-01
• Primary completion: 2006-09-01
• Completion: 2006-09-01
• First posted: 2008-03-07
• Last updated: 2008-03-10

Locations

1 site across 1 country: Croatia