NCT00631332

Women's Health Initiative Study of Cognitive Aging

Effects of Hormone Replacement Therapy on Cognitive Aging: Women's Health Initiative Study of Cognitive Aging (WHISCA)

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 2,303 (actual)
• Sponsor: Wake Forest University · Academic / Other
• Sex: Female
• Age: 65 Years – 90 Years
• Healthy volunteers: Accepted

Summary

The Women's Health Initiative Study of Cognitive Aging (WHISCA) is a two-armed, randomized, placebo controlled, clinical trial designed to assess the efficacy of postmenopausal hormone therapy (HT) on age related changes in specific cognitive functions.

Detailed description

WHISCA is an ancillary study to the Women's Health Initiative (WHI) and the WHI Memory Study (WHIMS) and has enrolled 2303 women aged 66 to 84 years who did not meet the criteria for dementia. WHISCA is investigating the effects of hormone therapy on rates of change over time in memory, other aspects of cognition (language, attention, spatial ability), motor function, and mood. Objectives * Does HT protect against age-associated memory and cognitive longitudinal decline in women age 65 and older? * What is the rate of change in memory and other cognitive abilities in women receiving HT compared to women receiving placebo? * Does the addition of progesterone to HT modify the effects of estrogen on memory and other cognitive abilities?

Conditions

• Healthy

Timeline

• Start date: 1999-07-01
• Primary completion: 2007-09-01
• Completion: 2008-06-01
• First posted: 2008-03-07
• Last updated: 2017-11-06

Locations

1 site across 1 country: United States