NCT00630955

Family History Study of Alcohol Consumption Using Memantine

NMDA Antagonist Efficacy in Reducing Human Alcohol Consumption: Impact of Family History

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 111 (actual)
• Sponsor: Yale University · Academic / Other
• Sex: All
• Age: 21 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to evaluate the effects of the study medication, memantine (placebo, 20 mg or 40 mg/day) on alcohol drinking behavior in a laboratory setting in which participants are given an initial drink of alcohol followed by the choice to drink up to 12 more drinks over a three-hour period. We hypothesize that memantine will reduce craving and number of drinks consumed prior to and after exposure to the initial drink of alcohol and during the three hour drinking period. We will also evaluate the influence of family history of alcoholism on the efficacy of memantine in reducing alcohol drinking behavior.

Conditions

• Alcohol Drinking

Interventions

Type	Name	Description
DRUG	memantine	Memantine 20 mg once per day for 7 days
DRUG	Memantine	Memantine 40 mg once per day for 7 days
DRUG	Placebo	Placebo once per day for 7 days

Timeline

• Start date: 2006-06-01
• Primary completion: 2011-05-01
• Completion: 2011-08-01
• First posted: 2008-03-07
• Last updated: 2020-03-17
• Results posted: 2014-03-05

Locations

1 site across 1 country: United States