NCT00630214

Prevention of Hypocalcemia in Patients Undergoing Total Thyroidectomy Plus Central Neck Dissection

Phase 2 Study of Routine Oral Calcium and Vitamine D Supplements to Prevent Hypocalcemia After Total Thyroidectomy in Papillary Thyroid Carcinoma Patients

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 200 (actual)
• Sponsor: Asan Medical Center · Academic / Other
• Sex: All
• Age: 15 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

the increased risk of hypocalcemia following total thyroidectomy plus central neck dissection can be minimized by routine administration of oral calcium and vitamin D supplements during the early postoperative period.

Detailed description

Of patients with differentiated papillary thyroid carcinoma, group D underwent total thyroidectomy alone and groups A-C underwent total thyroidectomy plus CND. The latter were randomized to oral calcium (3 g/day) plus vitamin D (1 mcg/day) (group A, n = 49), calcium alone (group B, n = 49), or no supplements (group C, n = 50). Hypocalcemic symptoms, serum calcium, and parathyroid hormone (PTH) levels were compared among the groups.

Conditions

• Hypocalcemia

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Oral calcium plus vitamin D	calcium supplementation took 3 g/day oral calcium (1 g every 8 h) plus 1 mcg/day vitamin D (0.5 mcg every 12 h), beginning on the night of surgery and continuing for 14 days.
DIETARY_SUPPLEMENT	Oral calcium alone	calcium carbonate (3 g/day, 1 g every 8 h)

Timeline

• Start date: 2004-05-01
• Primary completion: 2006-02-01
• Completion: 2006-02-01
• First posted: 2008-03-06
• Last updated: 2008-03-06

Locations

1 site across 1 country: South Korea