Trials / Terminated
TerminatedNCT00629577
Gene Expression Profiling of Cervical Cancer Progression in Biopsies and Tissue Samples
Ex Vivo Gene Expression Profiling of Cervical Cancer Progression in Biopsies And Tissue Samples From Patients With Cervical Lesions
- Status
- Terminated
- Phase
- Phase 1
- Study type
- Interventional
- Enrollment
- 50 (estimated)
- Sponsor
- British Columbia Cancer Agency · Academic / Other
- Sex
- Female
- Age
- 19 Years
- Healthy volunteers
- Not accepted
Summary
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research trial is studying gene expression profiling of cervical cancer progression in biopsies and tissue samples from patients with cervical lesions.
Detailed description
OBJECTIVES: * Classify cervical cancer progression at a molecular level using gene expression profiling generated from expression microarrays. * Profile gene expression changes of dysplasia and early carcinoma of uterine cervical tissue at a molecular level using expression microarrays. * Define a set of genes that classify the various grades of cervical cancer/dysplasia at a molecular level. * Compare the expression profiles of clinical data to determine how accurately cell lines model the in vivo environment. OUTLINE: Patients undergo colposcopy and a cervical smear is taken for flow cytometry analysis. Patients also undergo 2 biopsies from one clinically abnormal or normal site. Tissue samples are analyzed by gene expression profiling using human expression microarrays containing approximately 40,000 unique sequences. Data analysis consists of defining a set of genes, containing new targets for biomarkers, that classify the biopsies into 3 grades.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| GENETIC | microarray analysis | |
| OTHER | flow cytometry | |
| PROCEDURE | biopsy | |
| PROCEDURE | colposcopy |
Timeline
- Start date
- 2006-09-01
- Primary completion
- 2010-06-01
- Completion
- 2011-12-01
- First posted
- 2008-03-06
- Last updated
- 2017-02-01
Locations
1 site across 1 country: Canada
Source: ClinicalTrials.gov record NCT00629577. Inclusion in this directory is not an endorsement.