NCT00628706

Investigating the Acute Effects of THC on Functional Brain Systems

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 12 (estimated)
• Sponsor: UMC Utrecht · Academic / Other
• Sex: Male
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine whether THC, the main psychoactive ingredient in cannabis, affects functional brain systems underlying memory and reward.

Detailed description

Cannabis is by far the most frequently used illicit drug worldwide and has significant effects on memory. Further, cannabis has an addictive potential. These effects are mediated by an action of THC, the main psychoactive ingredient of cannabis, on cannabinoid CB1 receptors. These receptors are particularly highly expressed in brain regions involved in memory and reward. Therefore, in this study we will investigate the acute effects of THC on functional brain systems underlying memory and reward. We will visualize these effects using the latest non-invasive imaging technique: pharmacological MRI (phMRI).

Conditions

• Reward
• Tetrahydrocannabinol
• Endocannabinoids
• Memory
• Magnetic Resonance Imaging

Interventions

Type	Name	Description
DRUG	Delta9-tetrahydrocannabinol (THC)	inhalation of 6 mg liquid THC, vaporized by means of a Volcano vaporizer

Timeline

• Start date: 2008-04-01
• Primary completion: 2008-09-01
• Completion: 2008-09-01
• First posted: 2008-03-05
• Last updated: 2009-02-18

Locations

1 site across 1 country: Netherlands