NCT00627757

Antipsychotic Medicine and Metabolic Syndrome

Changes in Enteroendocrine and Neuroendocrine Axes in Patients With Weight Gain After Treatment With Antipsychotics

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: Glostrup University Hospital, Copenhagen · Academic / Other
• Sex: Male
• Age: 18 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

The purpose of the study is to determine whether antipsychotic treatment is influence psychiatric patients due to endocrine and metabolic status and a quality of life. The investigators expect, that 30-50% of patients will show pharmacon - gene induced weight gain (\> 7% of initial bodyweight) while the rest of patients will maintain unaltered bodyweight.

Detailed description

The primary aim of this study is to investigate status of neuro-and enteroendocrine axes with focus on beta - cell function in relation to insulin resistance, lipid profile abnormalities and inflammations adipokins in patients during treatment with antipsychotics (AP) in relation to weight gain. The second aim is to evaluate the connection between weight gain and patients´ own perception of their quality of life and health.

Conditions

• Metabolic Syndrome

Timeline

• Start date: 2008-02-01
• Primary completion: 2010-02-01
• Completion: 2010-12-01
• First posted: 2008-03-03
• Last updated: 2010-07-30

Locations

2 sites across 1 country: Denmark