Trials / Unknown
UnknownNCT00626145
Long Term Follow-up of Autologous Bone Marrow Mononuclear Cells Therapy in STEMI
Long Term Functional Evaluation After Intracoronary Delivery of Autologous Bone Marrow Mononuclear Cells in Patients With ST-Elevation Myocardial Infarction
- Status
- Unknown
- Phase
- Phase 1 / Phase 2
- Study type
- Interventional
- Enrollment
- 37 (actual)
- Sponsor
- Xijing Hospital · Academic / Other
- Sex
- All
- Age
- 45 Years – 65 Years
- Healthy volunteers
- Not accepted
Summary
The benefit of current reperfusion therapies for ST-elevation myocardial infarction (STEMI) is limited by post-infarction left ventricular (LV) dysfunction. Many clinic trails showed the short term outcome of bone marrow stem cell transplantation for MI patients, but rare report of long term follow-up results. Our aim was to investigate 4 years' efficacy and LV functional improvement of autologous bone marrow mononuclear cells (BMMC) transplantation in patients with ST-elevation myocardial infarction.
Detailed description
The benefit of current reperfusion therapies for ST-elevation myocardial infarction (STEMI) is limited by post-infarction left ventricular (LV) dysfunction. Many clinic trails showed the short term outcome of bone marrow stem cell transplantation for MI patients, but rare report of long term follow-up results. Aim is to evaluate the long term efficiency of unselected bone marrow mononuclear cells in treatment of patients with ST-elevation myocardial infarction (STEMI), especially with regard to the left ventricular function. The cells are delivered by intracoronary infusion 7 days after the PCI. Outcomes including LVEF, myocardial viability and coronary artery status are assessed by echocardiography, SPECT and coronary angiography.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | saline infusion | Patients receive intracoronary injections of saline 7 days after PCI. |
| PROCEDURE | autologous bone marrow mononuclear cells infusion | Patients receive intracoronary injections of autologous bone marrow mononuclear cells 7 days after PCI. |
Timeline
- Start date
- 2003-03-01
- Primary completion
- 2008-03-01
- Completion
- 2008-03-01
- First posted
- 2008-02-29
- Last updated
- 2008-02-29
Locations
1 site across 1 country: China
Source: ClinicalTrials.gov record NCT00626145. Inclusion in this directory is not an endorsement.