NCT00624559

The Role of COX-2 Inhibition in Salt Sensitivity of Blood Pressure

COX-2 Regulation of Renal Sodium Handling in Blood Pressure Maintenance

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: University of Delaware · Academic / Other
• Sex: All
• Age: 22 Years – 50 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine if the drug Celebrex changes the way the kidney gets rid of salt and maintains blood pressure.

Detailed description

There have been many studies done with analgesics such as acetaminophen and non-steroidal anti-inflammatory drugs; however it is not understood how blood pressure changes while using Celebrex. The study hypothesis is that Celebrex will increase salt sensitivity of blood pressure.

Conditions

• Hypertension

Interventions

Type	Name	Description
DRUG	celecoxib (Celebrex)	Celecoxib (Celebrex) was administered at 100 mg, twice per day for each day of sodium diet
OTHER	Placebo	Placebo pill taken twice per day on each day of the diet

Timeline

• Start date: 2008-02-01
• Primary completion: 2009-01-01
• Completion: 2009-01-01
• First posted: 2008-02-27
• Last updated: 2012-01-06
• Results posted: 2011-12-21

Locations

1 site across 1 country: United States