NCT00621387

Study of Long-Term Antibiotic Treatment in Reactive Arthritis

Double-Blind, Placebo-Controlled Study of Three-Month Treatment With the Combination of Ofloxacin and Roxithromycin in Recent-Onset Reactive Arthritis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 56 (actual)
• Sponsor: University of Helsinki · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This is a randomized, double-blind, placebo-controlled trial of the effect of 3-month treatment with the combination of 200 mg ofloxacin twice daily and 150 mg roxithromycin twice daily on clinical course of recent-onset reactive arthritis. Patients are followed-up at regular intervals until 6 months. The main outcome measure is recovery from arthritis, and secondary outcome measures include swollen and tender joint counts, Ritchie index, joint pain, serum C-reactive protein level and blood erythrocyte sedimentation rate. The study will also address the safety and tolerability of long-term antibiotic treatment. 56 patients are enrolled and the enrollment of patients has been completed.

Conditions

• Reactive Arthritis

Interventions

Type	Name	Description
DRUG	ofloxacin and roxithromycin	150 mg roxithromycin tablet twice daily and 200mg ofloxacin tablet twice daily for 3 months
DRUG	placebo	placebo tablets identical to ofloxacin and roxithromycin twice daily for 3 months

Timeline

• Start date: 1993-11-01
• Completion: 1998-06-01
• First posted: 2008-02-22
• Last updated: 2008-02-22

Locations

2 sites across 1 country: Finland