NCT00620204

Efficacy Study of Atorvastatin to Treat Variant Angina

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 136 (estimated)
• Sponsor: Samsung Medical Center · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

The objective of this study is to evaluate effect of statin treatment for vasospastic angina.

Detailed description

Vasospastic angina is presented by myocardial ischemia with spasm of coronary artery accompanying chest pain or discomfort. The precise mechanisms have not been established, but a reduction in NO (nitric oxide) production, an imbalance between endothelium-derived relaxing and contracting factors,or an injury of endothelium have been suggested. Impaired FMD(flow mediated endothelium-dependent vasodilation) in the brachial artery was demonstrated in vasospastic angina,and improvement of endothelial dysfunction with treatment of statin is documented in several studies. So, we expect that statin treatment for vasospastic angina provide additional therapeutic effects via improvement of endothelial dysfunction.

Conditions

• Angina Pectoris, Variant

Interventions

Type	Name	Description
DRUG	atorvastatin	atorvastatin 40mg qd for 1 year

Timeline

• Start date: 2008-01-01
• Primary completion: 2009-12-01
• Completion: 2010-12-01
• First posted: 2008-02-21
• Last updated: 2009-04-06

Locations

1 site across 1 country: South Korea