NCT00616057

Evaluation of Fructans Supplementation on Parameters of Metabolic Syndrome

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 34 (actual)
• Sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Academic / Other
• Sex: Female
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Obesity is constantly increasing, causing an important risk to develop diseases such as heart disease, diabetes,... Some recent studies have shown that obese people present modifications of colon microflora and a low-grade inflammation. In our laboratory, we have demonstrated that the intake of fructans lessens dietary intake, body weight gain, adipose tissue accumulation and steatosis in rodents. These effects lead to an improvement of insulin resistance and hyperglycemia in diabetic rats and mice. Fructans are also able to restore the microflora disturbed by a high fat diet and to prevent endotoxemia. Moreover, studies have shown that fructans intake promotes satiety (Cani et al, Diabetes 2007) and or decreases fat mass (Abrams et al, Journal of Pediatrics 2007) in healthy human. An intervention study in obese patients is thus needed to study the effects of fructans in the target population.

Conditions

• Obesity

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Synergy 1	8 grams/day during the first week and then 8 grams twice a day during 3 months
DIETARY_SUPPLEMENT	maltodextrin	8 grams/day during the first week and then 8 grams twice a day during 3 months

Timeline

• Start date: 2008-02-01
• Primary completion: 2010-05-01
• Completion: 2011-06-01
• First posted: 2008-02-15
• Last updated: 2012-07-06

Locations

1 site across 1 country: Belgium