NCT00615875

Naproxen for Acute Pain After Surgery: A Randomized, Placebo-Controlled Trial

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 24 (estimated)
• Sponsor: Hamilton Health Sciences Corporation · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine whether using an additional 48 hours of oral naproxen, after other post-operative pain medications have been stopped, will be effective in reducing opiate pain medication requirements and contribute to improved pain management.

Detailed description

At St. Joseph's Healthcare Hamilton, the Acute Pain Service (APS) is responsible for the immediate post-operative pain management of many surgical inpatients. While cared for by APS, the patient receives multimodal analgesia, including adjunctive medications (acetaminophen and naproxen/ketorolac) scheduled around the clock. When APS discontinues the epidural/pain pump, all adjunctive medications are discontinued and the patient is usually started on 'as needed' opiate or combination opiate (i.e. Tylenol#3) medications. On occasion, APS will write an order for an additional 48 hours of naproxen, but this practice has not been formally evaluated at this site. This randomized, placebo-controlled study proposes to evaluate this bridging strategy to see if regularly scheduled naproxen after discontinuation of other post-operative medications will affect the daily doses of opiate pain medications used, side effects of those opiate medications and pain scores of patients.

Conditions

• Pain, Postoperative

Interventions

Type	Name	Description
DRUG	naproxen	opaque pale orange suspension: 20mL q12h x 4 doses mixed in juice.
DRUG	placebo	opaque pale orange suspension: 20mL q12h x 4 doses mixed in juice

Timeline

• Start date: 2008-03-01
• Primary completion: 2008-05-01
• Completion: 2008-06-01
• First posted: 2008-02-14
• Last updated: 2008-02-14

Locations

1 site across 1 country: Canada