NCT00614913

Proton Beam Therapy for Treatment of Hepatocellular Carcinoma

Phase I/II Study of Proton Beam Therapy for Hepatocellular Carcinoma

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 76 (actual)
• Sponsor: Loma Linda University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study is designed to evaluate the possible benefits and side effects of the use of proton therapy for patients with hepatocellular carcinoma.

Detailed description

Hepatocellular carcinoma (HCC) is a type of primary cancer of the liver that is being diagnosed in the U.S. population with increasing frequency. While surgery is the first line of treatment, many patients are not eligible for surgical removal. Current non-surgical treatments for HCC are not fully effective and can have substantial side-effects. This study utilizes a type of radiation treatment called proton beam that can deliver high doses of radiotherapy to tumors within the liver while minimizing damage to surrounding healthy tissues. The treatment is non-invasive and is given on an out-patient basis over a three week coarse. The study will evaluate the effectiveness and side-effects of this therapy by tracking patient's outcomes following treatment.

Conditions

• Liver Cancer
• Hepatocellular Carcinoma

Interventions

Type	Name	Description
RADIATION	Proton radiation therapy	A total dose of 63 Gy will be delivered in 15 equally divided daily fractions over a 3 week coarse as an out-patient.

Timeline

• Start date: 1998-05-01
• Primary completion: 2009-02-01
• Completion: 2009-02-01
• First posted: 2008-02-13
• Last updated: 2012-08-20
• Results posted: 2012-08-20

Locations

1 site across 1 country: United States